[METTL3-mediated m<sup>6</sup>A modification promotes FOXO3 expression and anthracycline resistance in acute myeloid leukemia cells through autophagy regulation].
METTL3 promotes FOXO3 expression via m6A modification, and FOXO3-driven autophagy contributes to anthracycline resistance in AML cells by enhancing cell proliferation and suppressing cell apoptosis.
Authors
- Xiawei Zhang (ORCID: https://orcid.org/0000-0003-4070-9228)
- Chunji Gao (ORCID: https://orcid.org/0000-0003-4024-7588)
- Liping Dou (ORCID: https://orcid.org/0000-0001-7352-9560)
- Qingyang Liu (ORCID: https://orcid.org/0009-0002-8535-7203)
- Jingjing Yang (ORCID: https://orcid.org/0009-0004-3497-1785)
- Yanan Wen
Institutions
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-03-20
- DOI
- https://doi.org/10.12122/j.issn.1673-4254.2025.03.04
- Primary Topic
- PI3K/AKT/mTOR signaling in cancer
- Type
- article