Time-dependent effects of prone position on ventilation-perfusion matching assessed by electrical impedance tomography in patients with COVID-19 ARDS: sub-analysis of a prospective physiological study
In COVID-19-induced ARDS patients, prone positioning initially improves oxygenation and V/Q matching by enhancing ventilation distribution and decreasing low V/Q (%). Over time, perfusion changes further improve V/Q matching, but these benefits diminish once the patient returns to the supine position, leading to increased V/Q mismatch. Trial registration Clinical Trials.gov, NCT04725227. Registered 25 January 2021, https://clinicaltrials.gov/study/NCT04725227?cond=NCT04725227&rank=1.
Authors
- Zhanqi Zhao (ORCID: https://orcid.org/0000-0002-1279-2207)
- Yaxiaerjiang Muhetaer
- Xin Zheng (ORCID: https://orcid.org/0000-0003-0915-7787)
- Ming Zhong (ORCID: https://orcid.org/0000-0002-5578-5277)
- Wei Wu (ORCID: https://orcid.org/0000-0001-6159-3346)
- Yuxian Wang (ORCID: https://orcid.org/0000-0003-4169-4873)
- Ling Zhu (ORCID: https://orcid.org/0000-0001-9594-8467)
- Jieqiong Song
- Jiale Tao
Institutions
- Sun Yat-sen University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fudan University (CN)
- Peking Union Medical College Hospital (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Furtwangen University (DE)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Annals of Intensive Care
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1186/s13613-025-01452-0
- Citations
- 4
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 6.07
Funders
- State Key Laboratory of Respiratory Disease
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- Fudan University
- Science and Technology Innovation Plan Of Shanghai Science and Technology Commission