Long-term Physicochemical Stability of a Pharmaceutical Preparation of Morphine Hydrochloride and Droperidol in Polypropylene Syringes.

The pharmaceutical preparation of 2mg/mL morphine hydrochloride and 0.083 mg/mL droperidol in polypropylene syringes, stored in a light-protected environment at room temperature, displayed stability throughout the 50-days study period. It is noteworthy that even there were slight variations in pH and absorbance at 350 nm, these observations, to the best of our knowledge, do not contraindicate the preparation of this admixture in advance under aseptic conditions by a CIVAS. However, the compounding process must be validated for sterility, accuracy and reproducibility.