Low-density lipoprotein cholesterol, C-reactive protein, and lipoprotein(a) universal one-time screening in primary prevention: the EPIC-Norfolk study
A single combined measure of LDL cholesterol, hsCRP, and Lp(a) among initially healthy European men and women was predictive of incident MACE during a 20-year period. These data replicate findings from a recent American cohort and strongly support universal screening for all three biomarkers in primary prevention.
Authors
- G. Kees Hovingh (ORCID: https://orcid.org/0000-0002-8145-1676)
- Jordan M Kraaijenhof (ORCID: https://orcid.org/0000-0001-7566-6403)
- Ask Tybjærg Nordestgaard (ORCID: https://orcid.org/0000-0002-5500-686X)
- Nick S. Nurmohamed (ORCID: https://orcid.org/0000-0001-9045-6009)
- Laurens F. Reeskamp (ORCID: https://orcid.org/0000-0002-8043-951X)
- S. Matthijs Boekholdt (ORCID: https://orcid.org/0000-0002-0861-0765)
- Paul M. Ridker (ORCID: https://orcid.org/0000-0003-1249-4522)
- Erik S G Stroes (ORCID: https://orcid.org/0009-0000-7584-7677)
Institutions
- Brigham and Women's Hospital (US)
- Gentofte Hospital (DK)
- Amsterdam University Medical Centers (NL)
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- European Heart Journal
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1093/eurheartj/ehaf209
- Citations
- 39
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 78.25