[<i>Akkermansia muciniphila</i> gavage improves gut-brain interaction disorders in gp120 transgenic mice].
The gp120tg mice have lower intestinal microbiota richness and diversity than WT mice. The 12-month-old gp120tg mice have significantly reduced <i>Akkermansia</i> abundance with distinct DGBIs-related indexes, and <i>A. muciniphila</i> gavage can reduce intestinal barrier injury, colonic inflammation and eosinophil activation, cognitive impairment and brain neuron injury in these mice.
Authors
- Xuefeng Gao (ORCID: https://orcid.org/0000-0002-1174-0536)
- Zhihui Yu (ORCID: https://orcid.org/0000-0003-4443-7645)
- Siqi Xiong (ORCID: https://orcid.org/0000-0002-1281-8198)
- Jingyu Chen (ORCID: https://orcid.org/0000-0002-2127-1788)
- Hong Cao (ORCID: https://orcid.org/0000-0001-9138-465X)
- Jiachun Luo
- Sodnomjamts Batzaya
Institutions
- Southern Medical University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-03-20
- DOI
- https://doi.org/10.12122/j.issn.1673-4254.2025.03.13
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article