Lactate orchestrates metabolic hemodynamic adaptations through a unique combination of venocontraction, artery relaxation, and positive inotropy
Carboxylate metabolites generally relax arteries and veins. L-lactate relaxes arteries, lowering systemic vascular resistance, causes preferential venocontraction with increased ventricular diastolic filling, and elevates cardiac contractility and cardiac output. We propose that L-lactate optimizes cardiovascular function during metabolic disturbances.
Authors
- Ebbe Boedtkjer (ORCID: https://orcid.org/0000-0002-5078-9279)
- Jacob Seefeldt (ORCID: https://orcid.org/0000-0002-0633-5878)
- Roni Nielsen (ORCID: https://orcid.org/0000-0001-9228-3869)
- Jakob Hansen (ORCID: https://orcid.org/0000-0002-4115-2858)
- Frank Vincenzo de Paoli (ORCID: https://orcid.org/0000-0002-2174-2295)
- Casper Homilius (ORCID: https://orcid.org/0000-0002-8618-8109)
Institutions
- Aarhus University (DK)
- Aarhus University Hospital (DK)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1111/apha.70037
- Citations
- 10
- Primary Topic
- Heart Rate Variability and Autonomic Control
- Type
- article
- Field-Weighted Citation Impact
- 13.88
Funders
- Danmarks Frie Forskningsfond
- Novo Nordisk Fonden
- Fonden til Lægevidenskabens Fremme