Mitochondrial Complex I Molecular Alterations in <i>Sapajus apella</i> as a Human Gastric Carcinogenesis Model After <scp>MNU</scp> Exposure
Two synonymous alterations were identified in ND1. In ND3, a non-synonymous alteration (A10398G ➔ Thr114Ala) may decrease the respiratory chain Complex I efficiency, enhancing cellular reactive oxygen species and contributing to mtDNA damage. As alterations in ND1 and ND3 were observed in highly aggressive cell lines, our results suggest these genes may play crucial roles in energetic efficiency and gastric carcinogenesis.
Authors
- Bárbara do Nascimento Borges (ORCID: https://orcid.org/0000-0002-5989-8287)
- Danilo do Rosário Pinheiro (ORCID: https://orcid.org/0000-0002-6301-5272)
- Bárbara dos Santos Dias (ORCID: https://orcid.org/0009-0004-5643-4518)
- Rommel Mário Rodríguez Burbano (ORCID: https://orcid.org/0000-0002-4872-234X)
- Symara Rodrigues-Antunes (ORCID: https://orcid.org/0000-0001-7346-0700)
Institutions
- Hospital Israelita Albert Einstein (BR)
- Universidade Federal Rural da Amazônia (BR)
- Amazon Research Foundation (BR)
- Universidade Federal do Pará (BR)
Publication Details
- Journal
- Journal of Medical Primatology
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1111/jmp.70017
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico