Infectious Complications in Patients Treated With T-cell Engagers as Cancer Immunotherapies, a Descriptive Study From the REISAMIC Registry
We investigated infectious complications and the associated risk factors in 181 patients undergoing T-cell engagers for malignancies. Infections were primarily observed in patients with hematological diseases or heavily pre-treated. Mortality due to infectious complications was 2.8%. Concomitant medications with corticosteroids or tocilizumab did not significantly impact the incidence of infections.
Authors
- Élisabeth Chachaty (ORCID: https://orcid.org/0000-0001-7916-7660)
- Salim Laghouati (ORCID: https://orcid.org/0000-0003-0888-0842)
- Justin Cagnat
- Cristina Smolenschi (ORCID: https://orcid.org/0000-0002-7568-6196)
- M. Haberstich
- Kaïssa Ouali (ORCID: https://orcid.org/0000-0002-8269-3001)
- Benjamin Besse (ORCID: https://orcid.org/0000-0001-5090-8189)
- Anas Gazzah (ORCID: https://orcid.org/0000-0002-6866-6787)
- Capucine Baldini (ORCID: https://orcid.org/0000-0002-0604-7614)
- Vincent Ribrag (ORCID: https://orcid.org/0000-0002-5221-353X)
- Thomas Hueso (ORCID: https://orcid.org/0000-0003-3354-332X)
- Sabine Messayke (ORCID: https://orcid.org/0000-0001-8380-4941)
- Rastislav Bahleda (ORCID: https://orcid.org/0009-0001-8245-0544)
- Ariane Laparra (ORCID: https://orcid.org/0000-0002-8275-7044)
- Madona Sakkal (ORCID: https://orcid.org/0000-0002-9015-8359)
- Véronique Minard‐Colin (ORCID: https://orcid.org/0000-0002-0296-5207)
- Aurélien Marabelle (ORCID: https://orcid.org/0000-0002-5816-3019)
- Camille Bigenwald (ORCID: https://orcid.org/0000-0003-2714-2087)
- Charlotte Rigaud (ORCID: https://orcid.org/0000-0002-1774-778X)
- Jean‐Marie Michot (ORCID: https://orcid.org/0000-0003-3482-3331)
- Antoine Hollebecque (ORCID: https://orcid.org/0000-0003-2869-7551)
- Fabrice Barlési (ORCID: https://orcid.org/0000-0001-5793-3539)
- Mansouria Merad
- Christophe Massard (ORCID: https://orcid.org/0000-0001-5505-0564)
- Benoît Henry (ORCID: https://orcid.org/0000-0003-4916-4121)
- Alina Danu
- O. Lambotte
Institutions
- Inserm (FR)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- Institut Gustave Roussy (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Prometheus Research (United States) (US)
- CEA Paris-Saclay (FR)
- Prometheus (United States) (US)
- Bicêtre Hospital (FR)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1093/cid/ciaf164
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00