[Protein C activator derived from snake venom protects human umbilical vein endothelial cells against hypoxia-reoxygenation injury by suppressing ROS <i>via</i> upregulating HIF-1α and BNIP3].
Snake venom PCA alleviates OGD/R-induced endothelial cell injury by upregulating HIF-1α/BNIP3 signaling to suppress ROS generation, suggesting its potential as a therapeutic agent against oxidative stress in vascular pathologies.
Authors
- Ming Liao (ORCID: https://orcid.org/0000-0003-4217-1142)
- Ran Zhang (ORCID: https://orcid.org/0000-0002-0921-078X)
- Chao Wu (ORCID: https://orcid.org/0000-0001-8304-5973)
- Wenxia Xu (ORCID: https://orcid.org/0000-0002-9018-4784)
- Juan Liang (ORCID: https://orcid.org/0000-0002-0952-6186)
- Wenhua Zhong
- Wenjun Wan (ORCID: https://orcid.org/0009-0001-1752-8819)
- 曙 李
Institutions
- Wannan Medical College (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-03-20
- DOI
- https://doi.org/10.12122/j.issn.1673-4254.2025.03.19
- Primary Topic
- Blood Coagulation and Thrombosis Mechanisms
- Type
- article