Neurological disability and brain grey matter atrophy in primary progressive multiple sclerosis are determined by microstructural lesional changes, but not by lesion load
Quantitative lesional MRI measures, but not lesion load, were strongly associated with clinical disability and GM atrophy in PPMS patients, likely reflecting differences in lesion pathology between MS subtypes.
Authors
- Jan Bauer (ORCID: https://orcid.org/0000-0001-5802-8047)
- Carsten Lukas (ORCID: https://orcid.org/0000-0002-8562-9697)
- Theodoros Ladopoulos (ORCID: https://orcid.org/0009-0006-1735-4130)
- Jeyanthan Charles James (ORCID: https://orcid.org/0000-0002-7192-2120)
- Ruth Schneider (ORCID: https://orcid.org/0000-0002-0997-2725)
- Ralf Gold (ORCID: https://orcid.org/0000-0002-7223-3052)
- Zainab Abbas (ORCID: https://orcid.org/0000-0002-2948-7401)
- Britta Krieger
- Barbara Bellenberg (ORCID: https://orcid.org/0000-0001-7484-6787)
Institutions
- University Hospitals of the Ruhr-University of Bochum (DE)
- St. Josef-Hospital (DE)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1007/s00415-025-13043-x
- Citations
- 2
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- Ruhr-Universität Bochum