Synergistic antifungal activity of minocycline as an effective augmenting agent of fluconazole against drug-resistant <i>Candida tropicalis</i>
This study highlights the potential of minocycline and fluconazole combination therapy in combating drug-resistant <i>Candida tropicalis</i>. It shows promising <i>in vitro</i> and <i>in vivo</i> synergistic effects, reducing MIC and enhancing fungicidal activity. Further clinical trials are needed to validate its efficacy in treating FLC-resistant <i>C. tropicalis</i> infections.
Authors
- Yun-Zhu Zhu
- Yasheng Li (ORCID: https://orcid.org/0009-0002-5703-6445)
- Liang Yu (ORCID: https://orcid.org/0000-0002-2020-1446)
- Ping Tian (ORCID: https://orcid.org/0000-0002-5612-0664)
- Ning Yang
- Xiang Li (ORCID: https://orcid.org/0000-0002-1945-0381)
- Yanyan Liu (ORCID: https://orcid.org/0000-0003-1857-6377)
- Ding Zhang (ORCID: https://orcid.org/0000-0002-8334-8349)
- Jiabin Li (ORCID: https://orcid.org/0000-0002-6539-1802)
- Yi Yang (ORCID: https://orcid.org/0000-0002-0045-215X)
- Qingyue Zhang (ORCID: https://orcid.org/0000-0002-4992-1711)
- Ying Ye
Institutions
- Anhui Medical University (CN)
- Hong Kong University of Science and Technology (HK)
- Linyi People's Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1128/spectrum.03185-24
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China