The Significance of Extended HPV Genotyping for Detecting Endocervical Glandular Neoplasia for Atypical Glandular Cells
Atypical glandular cells was rarely related to CIN3. Atypical glandular cells was strongly related to AIS and EC-ADC. Women aged 30-49 years had highest risk for AIS/CIN3+ lesions. Although HPV test can be helpful, there were still some cases of HPV-negative endocervical adenocarcinomas. Extended HPV genotyping in AGC cases identified certain HPV types associated with a higher risk of cervical glandular lesions, potentially assisting with risk stratification.
Authors
- Jianan Xiao
- Xiang Tao (ORCID: https://orcid.org/0000-0002-1052-118X)
- Fangfang Zhong (ORCID: https://orcid.org/0000-0002-8772-5009)
- Chengquan Zhao (ORCID: https://orcid.org/0000-0001-7524-3048)
- Megan L Zilla (ORCID: https://orcid.org/0000-0003-2473-4474)
- Hao Zhang (ORCID: https://orcid.org/0000-0003-4093-5647)
- Yihua Sun (ORCID: https://orcid.org/0000-0002-5287-0601)
- Xianxu Zeng (ORCID: https://orcid.org/0000-0002-0457-9908)
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Magee-Womens Hospital (US)
- University of Pittsburgh Medical Center (US)
- Third Affiliated Hospital of Zhengzhou University (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
Publication Details
- Journal
- Journal of Lower Genital Tract Disease
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1097/lgt.0000000000000886
- Citations
- 1
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 1.35