Electrochemiluminescence imaging for immunoassay of prostate-specific antigen utilizing AIE-active polymer dots as the probe
We report, for the first time to the best of our knowledge, an electrochemiluminescent (ECL) immunosensor for the imaging analysis of prostate-specific antigen, using aggregation-induced-emission-active polymer dots (Pdots) as emitters. Assisted by rolling circle amplification, the immunosensor exhibits high sensitivity, with a low detection limit of 4.2 pg mL<sup>-1</sup>. This work demonstrates the potential of AIE-active Pdots in clinical applications.
Authors
- Huajian Gao (ORCID: https://orcid.org/0000-0002-8656-846X)
- Lingling Xu (ORCID: https://orcid.org/0000-0001-5760-2174)
- Qin Xu (ORCID: https://orcid.org/0000-0001-9311-213X)
- Jiayuan Zhu (ORCID: https://orcid.org/0000-0002-3641-4489)
Institutions
- Yangzhou University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc01035g
- Citations
- 5
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 4.03