Alstoscholarisine M, a 6,7-<i>seco</i>-vallesamine monoterpenoid indole alkaloid with antimicrobial activity from <i>Alstonia scholaris</i>
Alstoscholarisine M is a 6,7-<i>seco</i>-vallesamine monoterpenoid indole alkaloid with a rare methylcarbamate fragment, isolated from the leaves of <i>Alstonia scholaris</i>. Extensive spectroscopic data analyses, quantum chemical computations, and single-crystal X-ray diffraction elucidated its structure. The fascinating compound exhibited potential antifungal activity against <i>Trichophyton rubrum</i>, and its activity was roughly comparable to the first-line antifungal drug griseofulvin and significantly more effective than berberine, an important antimicrobial drug originating from plants.
Authors
- Cai-Feng Ding
- Xiao‐Nian Li
- Lan Chun Zhang
- Khalid-Hassan Mohamed (ORCID: https://orcid.org/0009-0007-6837-4534)
- Rongping Zhang (ORCID: https://orcid.org/0000-0002-0349-2982)
- Xiao-Dong Luo (ORCID: https://orcid.org/0009-0008-4777-4261)
- Jian-Neng Yao (ORCID: https://orcid.org/0000-0002-5844-3352)
- Hao Yu (ORCID: https://orcid.org/0000-0002-3944-3162)
- Lei Li (ORCID: https://orcid.org/0000-0002-9542-4767)
- Yaping Liu (ORCID: https://orcid.org/0000-0002-2164-2489)
Institutions
- Kunming Institute of Botany (CN)
- Yunnan University (CN)
- Chinese Academy of Sciences (CN)
- Kunming Medical University (CN)
- Yunnan University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob00420a
- Primary Topic
- Alkaloids: synthesis and pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.00