Entrectinib-induced Brugada syndrome leading to ventricular tachycardia in a patient with ROS1 fusion-positive lung adenocarcinoma

The relationship between entrectinib and drug-induced Brugada syndrome remains unclear, and reports of entrectinib-induced Brugada syndrome are rare.We performed risk stratification using electrophysiological examinations in a case of entrectinib-induced Brugada syndrome in a patient with ROS1 fusion-positive lung adenocarcinoma.Our results suggest that continuous electrocardiogram monitoring or frequent electrocardiogram recording at least once a day several days following entrectinib initiation may help detect entrectinib-induced Brugada syndrome irrespective of being in or out of hospital.