Research Advances in the Pathogenesis, Diagnosis, and Treatment of Kümmell’s Disease

Kümmell病(Kümmell’s disease, KD)是一种较为复杂的脊柱疾病，目前发病机制尚不明确，它是一种由椎体骨质损伤与修复过程相互作用所导致的椎体缺血性坏死以及椎体内假关节形成等多因素相互作用所形成。其常继发于骨质疏松性椎体压缩性骨折(OVCF)，多见于老年女性患者，KD的存在严重影响患者生活及生存的质量。近年来，随着人口老龄化加剧，Kümmell病的发病率呈上升趋势。本文将从Kümmell病的流行病学、病理生理学、诊断及治疗进展等方面进行综述。Kümmell’s disease (KD) is a complex spinal disorder with an unclear pathogenesis. It results from the interplay between vertebral bone injury and the repair process, leading to vertebral ischemic necrosis and the formation of intravertebral pseudarthrosis. KD often follows osteoporotic vertebral compression fractures (OVCF) and is more common in elderly female patients. The presence of KD significantly impacts the patient’s quality of life and survival. In recent years, with the aging population, the incidence of Kümmell’s disease has been increasing. This article reviews the epidemiology, pathophysiology, diagnosis, and treatment advancements of Kümmell’s disease.