Is miR-10a a tumor suppressor that modulates proliferation and invasion in high-grade bladder cancer?
The T24 cells transfected with miR-10a presented decreased cellular proliferation and invasion compared to the Scramble (<i>p</i> = 0.0481 and <i>p</i> < 0.0001, respectively). In the RT4 cell line, there was only a significant reduction in cellular proliferation after miR-10a transfection (<i>p</i> = 0.0029). <b>Conclusions:</b> Our findings suggest that miR-10a has a tumoral suppressor role in BC, demonstrating higher efficacy in high-grade cells.
Authors
- William Carlos Nahas (ORCID: https://orcid.org/0000-0002-7395-8370)
- Iran Amorim Silva
- Juliana Alves de Camargo (ORCID: https://orcid.org/0000-0001-5624-3798)
- Ruan Pimenta (ORCID: https://orcid.org/0000-0002-3423-5647)
- Nayara Izabel Viana (ORCID: https://orcid.org/0000-0003-4505-8508)
- Karina Serafim da Silva (ORCID: https://orcid.org/0000-0003-4854-9302)
- Sabrina T Reis
- Patrícia Candido (ORCID: https://orcid.org/0000-0001-5887-5617)
- Kátia Ramos Moreira Leite (ORCID: https://orcid.org/0000-0002-2615-7730)
- Carolina Mie Mioshi
- Vanessa Guimarães (ORCID: https://orcid.org/0000-0001-7502-4590)
- Gabriel Arantes dos Santos (ORCID: https://orcid.org/0000-0003-1602-9193)
- Poliana Romão (ORCID: https://orcid.org/0000-0003-0410-2349)
- Fernando Cotait Maluf (ORCID: https://orcid.org/0000-0002-4288-9018)
- Tiago André Moura Rodrigues (ORCID: https://orcid.org/0009-0001-9623-0761)
Institutions
- Federal Institute of São Paulo (BR)
- Morpho (United States) (US)
- Universidade do Estado de Minas Gerais (BR)
- Instituto do Câncer do Estado de São Paulo (BR)
- D’Or Institute for Research and Education (BR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Centro Universitário São Camilo (BR)
Publication Details
- Journal
- Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
- Published
- 2025-01-01
- DOI
- https://doi.org/10.32604/or.2025.055306
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00