Interleukin 17-producing C-C motif chemokine receptor 6 + conventional CD4+ T cells are arthritogenic in an animal model of spondyloarthritis
Our study demonstrates that IL-17<sup>+</sup>TNF<sup>+</sup>CCR6<sup>+</sup> Th17 cells and IL-17<sup>+</sup> γδ T cells are expanded preceding SpA onset in B27 rats and that only IL-17<sup>+</sup>TNF<sup>+</sup>CCR6<sup>+</sup> Th17 cells can trigger arthritis.
Authors
- M. Jacoutot
- Simon Glatigny (ORCID: https://orcid.org/0000-0001-9633-2074)
- Marie Beaufrère (ORCID: https://orcid.org/0000-0003-3622-122X)
- Gina Cosentino
- Tom Hutteau‐Hamel (ORCID: https://orcid.org/0009-0002-2399-686X)
- Roula Said Nahal
- Maxime Bréban (ORCID: https://orcid.org/0000-0002-6932-9395)
- Gaëlle Clavel (ORCID: https://orcid.org/0000-0002-5905-9969)
- Luiza M. Araujo
- Aude Jobart Malfait
Institutions
- Inserm (FR)
- Université de Versailles Saint-Quentin-en-Yvelines (FR)
- Université Paris Cité (FR)
- Université Paris-Saclay (FR)
- Sorbonne Université (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
Publication Details
- Journal
- Journal of Autoimmunity
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1016/j.jaut.2025.103413
- Citations
- 2
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 1.59