Allylic Acetal as 3C Synthon in Rh(III)-Catalyzed Divergent C–H Activation/[4 + 3] Annulation: Easy Access to Benzodiazepines
A concise synthesis of benzodiazepines via Rh(III) catalyzed C-H activation/ [4 + 3] annulation of easily available 1-arylpyrazolidinones with allylic acetal has been developed. The allylic acetal was employed as a novel 3C synthon in this transformation. Benzodiazepines were built under mild reaction conditions with high efficiency and chemoselectivity. The high atom-economy and easily accessible substrates reveal potential application.
Authors
- Yangjie Wu (ORCID: https://orcid.org/0000-0002-0134-0870)
- Xiuling Cui (ORCID: https://orcid.org/0000-0001-5759-766X)
- Chao Pi (ORCID: https://orcid.org/0000-0002-3404-1543)
- Mingming Hu (ORCID: https://orcid.org/0000-0002-6626-9657)
Institutions
- Zhengzhou University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1021/acs.orglett.4c04396
- Citations
- 5
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 4.68
Funders
- Science and Technology Department of Henan Province