The Jieduan-Niwan Formula Reduces Inflammatory Responses in Acute-on-Chronic Liver Failure Rats by Inhibiting HMGB1-Induced Hepatocyte Pyroptosis
The JDNWF protects the livers of ACLF rats by inhibiting HMGB1-induced hepatocyte pyroptosis reducing inflammatory responses, suggesting that HMGB1-induced hepatocyte pyroptosis may be a potential therapeutic target of ACLF.
Authors
- Chongyang Ma (ORCID: https://orcid.org/0000-0003-1481-8017)
- Xiaoyi Wei (ORCID: https://orcid.org/0000-0001-8978-4881)
- Weixin Hou (ORCID: https://orcid.org/0000-0001-8451-6335)
- Jiajun Liang
- Peng Fang (ORCID: https://orcid.org/0000-0002-1256-2241)
- Qiuyun Zhang (ORCID: https://orcid.org/0000-0002-7319-0031)
- Yanbin Gao (ORCID: https://orcid.org/0009-0006-9554-8969)
- Jingnan Li (ORCID: https://orcid.org/0000-0002-9578-2580)
Institutions
- Zhejiang Chinese Medical University (CN)
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- TCM-Intigrated Cancer Center of Southern Medical University (CN)
- Beijing Friendship Hospital (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/dddt.s488659
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 0.00