Overestimation of Automated Platelet Counts by Blast Fragments in Acute Hypercellular Leukemias: A Retrospective Study Comparing Impedance, Optical (<scp>PLT</scp>‐O), Fluorescent (<scp>PLT</scp>‐F), and <scp>CD41</scp>/<scp>CD61</scp> Flow Cytometry
PLT-O and PLT-F methods both have limitations in hypercellular acute leukemias with blast fragments. FC remains the most reliable approach when blast fragments are present. Routine blood smear evaluations are essential for detecting interferences and ensuring accurate thrombocytopenia assessment in these high-risk patients.
Authors
- Victor Bobée (ORCID: https://orcid.org/0000-0002-9357-4542)
- Maïssa Souissi
- Cédric Paquin
- Virginie Barbay (ORCID: https://orcid.org/0000-0002-4525-6611)
- Catherine Boutet
- Dany Bigot
- Sylvie Daliphard
- Elsa Bera
- Romain Ravel‐Chapuis
- Vincent Camus
- Jorel Gruchet
Institutions
- Centre Henri Becquerel (FR)
- Université de Rouen Normandie (FR)
Publication Details
- Journal
- International Journal of Laboratory Hematology
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1111/ijlh.14464
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00