Assessing Microneedling’s Effectiveness as an Advanced Drug Delivery System

Sir, Microneedling is also known as percutaneous collagen induction therapy which acquired significant attention in dermatology and cosmetic medicine. Beyond its traditional role in skin rejuvenation, it has potential as a highly effective drug delivery system. In microneedling therapy, fine needles are used to create microchannels in the skin, which improve the permeability of therapeutic agents and microneedling can accelerate the transdermal delivery of drugs by up to 1000 times compared to traditional methods. Transdermal absorption of lidocaine and tetracaine was improved significantly which leading to more effective local anesthesia.[1] Microneedling therapy suggestively improves the delivery of drugs and proper absorption of drugs. Microneedling therapy can effectively deliver hydrophilic molecules, peptides, and vaccines that typically cannot penetrate the skin barrier. Microneedling therapy reducing the risk of infection and improving patient compliance compared to other delivery systems such as hypodermic needles and patients experienced less pain and comfort with microneedling therapy.[2] Microneedling has used for different of applications including from treating localized conditions such as acne and alopecia to systemic drug delivery for diabetes conditions. This improvement makes it a valuable method in dermatology and cosmetic medicine. Furthermore, compared to other advanced drug delivery systems, the cost of microneedling tools and procedures is relatively low that making innovative treatments more easily accessible to a large patient flow.[3] The effectiveness of microneedling can be different depending on the drug type, the skin condition, and the most important is technique which is used. Consistent and good results require standard procedures, which is currently neglecting in clinical practices. Although microneedling therapy is generally safe, if it is not performed under sterile conditions microneedling carries risks such as infection, hyperpigmentation, and scarring.[4] Not all drugs reacts properly or suitable for delivery with the help of microneedling therapy. Molecules with large size may not penetrate effectively the microchannels. For effective microneedling skilled practitioners should be skilled to confirm proper technique and avoid complications and risk, which can limit its prevalent adoption, especially in resource-constrained places.[5] In conclusion, microneedling therapy has enhanced drug delivery system. It improves drug absorption and it has minimal invasiveness, versatility, and cost-effectiveness. Standardization is important to fully connect the potential of microneedling in clinical practices. Financial support and sponsorship Nil. Conflicts of interest There are no conflicts of interest.