The Hallmarks of Cancer as Eco-Evolutionary Processes
Viewing the hallmarks as a sequence of adaptations captures the "why" behind the "how" of the molecular changes driving cancer. This eco-evolutionary view distils the complexity of cancer progression into logical steps, providing a framework for understanding all existing and emerging hallmarks of cancer and developing therapeutic interventions.
Authors
- Stanislav Avdieiev (ORCID: https://orcid.org/0000-0002-1078-1459)
- Robert A. Gatenby (ORCID: https://orcid.org/0000-0002-1621-1510)
- Kenneth Yee Tsai (ORCID: https://orcid.org/0000-0001-5325-212X)
- Anuraag Bukkuri (ORCID: https://orcid.org/0000-0002-3616-626X)
- Christopher J. Whelan (ORCID: https://orcid.org/0000-0001-7511-2603)
- Joel S. Brown (ORCID: https://orcid.org/0000-0002-0958-9494)
- Ranjini Bhattacharya (ORCID: https://orcid.org/0000-0002-5045-9333)
Institutions
- University of Pittsburgh (US)
- University of South Florida (US)
- Moffitt Cancer Center (US)
- University of Illinois Chicago (US)
- UPMC Hillman Cancer Center (US)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-0861
- Citations
- 9
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 8.43
Funders
- National Cancer Institute