Sevoflurane pretreatment alleviates hypoxia-reoxygenation-induced myocardial cell injury by upregulating miR-21-5p
Mechanistically, we demonstrate for the first time that sevoflurane alleviates myocardial cell injury in myocardial I/R by upregulating miR-21-5p, thereby reducing inflammation, apoptosis, and oxidative stress in myocardial cells. This finding provides a potential therapeutic target for improving myocardial I/R.
Authors
- Hui Chen (ORCID: https://orcid.org/0000-0003-0361-3593)
- Shuang Qiu (ORCID: https://orcid.org/0000-0003-1489-2145)
- Jiang Qiu (ORCID: https://orcid.org/0009-0007-1910-4028)
Institutions
- Shanghai Traditional Chinese Medicine Hospital (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-04-01
- DOI
- https://doi.org/10.3389/fcvm.2025.1515160
- Citations
- 3
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 4.41