Fabrication of PVTF/COL Composite Films and Its Impact on Osteogenic Differentiation

Bone tissue is intrinsically electroactive, and electrical signaling is one of its key regulatory mechanisms. The electroactive poly (vinylidene fluoride trifluoroethylene) (PVTF), due to its piezoelectricity, can provide electrical stimulation to cells, regulating their proliferation and osteogenic differentiation. Collagen I (COL) is the main organic component of bone and is involved in various physiological processes of bone. A crucial question that remains to be explored is whether electroactive materials can meet the requirements for GBR membranes and what synergistic effects electrical signals and collagen’s biochemical signals might have on cellular behavior. In this study, PVTF/COL composite films were prepared using polydopamine (PDA). It was found that collagen modification could increase the surface Kelvin potential of PVTF from −5.07 V to 2.22 V, reduce the WCA from 98.9° to 33.2°, and maintain the tensile strength of PVTF at 24.94 MPa. Additionally, the composite film significantly promoted the adhesion and proliferation of bone marrow stem cells (BMSCs), and the ALP activity on PPC3 films after 7 days was 5.6 times higher than that on P films. This study presents a novel and effective approach for surface modification of PVTF and explores its potential applications in GBR.