Methylation patterns of the nasal epigenome of hospitalized SARS-CoV-2 positive patients reveal insights into molecular mechanisms of COVID-19
This study demonstrated DNA methylation as a marker of the immune response to SARS-CoV-2 infection, with enhancer-like elements playing significant roles. It is difficult to discern whether this differential methylation is a predisposing factor to severe COVID-19, or if methylation differences occur in response to disease severity. These differences in the nasal methylome may contribute to disease severity, or conversely, the nasal immune system may respond to severe infection through differential immune cell recruitment and immune function, and through differential regulation of the inflammatory response.
Authors
- Benjamin L. Spector (ORCID: https://orcid.org/0000-0003-1800-4715)
- Todd Bradley (ORCID: https://orcid.org/0000-0002-1601-631X)
- Rebecca McLennan (ORCID: https://orcid.org/0000-0002-0582-3220)
- Boryana Koseva (ORCID: https://orcid.org/0000-0002-8889-9377)
- Elin Grundberg (ORCID: https://orcid.org/0000-0001-5415-7896)
- Rangaraj Selvarangan (ORCID: https://orcid.org/0000-0003-3275-6657)
- Kamani Lankachandra
- Dithi Banerjee (ORCID: https://orcid.org/0009-0008-5005-736X)
Institutions
- Children's Mercy Hospital (US)
- University of Wisconsin–Madison (US)
- Mercy Hospital (US)
- Mercy Research (US)
- University of Missouri–Kansas City (US)
Publication Details
- Journal
- BMC Medical Genomics
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1186/s12920-025-02125-4
- Primary Topic
- Immune responses and vaccinations
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Frontiers Clinical and Translational Science Institute, University of Kansas