Physical activity of moderate-intensity optimizes myocardial citrate cycle in a murine model of heart failure
Moderate-intensity physical activity, even of short duration, could be considered an effective intervention in heart failure. Our results suggest that central metabolic pathway - TCA cycle appears to be more sensitive to moderate-intensity physical activity (as reflected by the lowering of myocardial citrate concentration) than the mechanism(s) regulating the BCAAs turnover in the heart. This observation may have a particular importance in heart failure, since an improvement of impaired myocardial oxidative metabolism may contribute to the upgrading of the clinical status of patients.
Authors
- Jerzy A. Żołądź (ORCID: https://orcid.org/0000-0002-1143-5590)
- Zenon Nieckarz (ORCID: https://orcid.org/0000-0002-2746-2534)
- Joanna Majerczak (ORCID: https://orcid.org/0000-0003-0898-1707)
- Stefan Chłopicki (ORCID: https://orcid.org/0000-0002-2878-3858)
- Anna Kurpińska (ORCID: https://orcid.org/0000-0003-2130-0099)
- Ryszard T. Smoleński (ORCID: https://orcid.org/0000-0002-0190-9414)
- Joanna Szramel
- Lucyna Widacha
Institutions
- Jagiellonian University (PL)
- Institute of Physics (PL)
- Gdańsk Medical University (PL)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-04-02
- DOI
- https://doi.org/10.3389/fphys.2025.1568060
- Citations
- 2
- Primary Topic
- Cardiovascular and exercise physiology
- Type
- article
- Field-Weighted Citation Impact
- 4.76
Funders
- Narodowe Centrum Nauki