Phytochemical and in vitro antimicrobial and antidiabetical activities of Cordiera sessilis stem bark
Studies based on medicinal plants have stood out as a complementary treatment intervention to type 2 Diabetes mellitus and its complications. Among the Brazilian medicinal plants, we highlight Cordiera sessilis (Vell.) Kuntze, in turn, has been studied in several chemical and biological studies due to its ethnopharmacological indications. Thus, this study aimed to evaluate the antimicrobial, antioxidant, antiglycation, and digestive enzyme inhibition effects of the fractions obtained from the ethanolic extract of the stem bark of C. sessilis. The results indicated that the dichloromethane, ethyl acetate, and n-butanol were the most promising fractions and therefore their phytochemical constitution was suggested by mass spectrometry. Several bioactive compounds belonging to the six classes were found, with a predominance of compounds from the flavonoid class, whose presence justifies the observed results. Thus, this study presented new results on the biological activities of this plant, contributing to the understanding of the action and effectiveness of its use in the management of diabetes mellitus and its complications.
Authors
- Allisson Benatti Justino (ORCID: https://orcid.org/0000-0003-3616-6611)
- Foued Salmen Espíndola (ORCID: https://orcid.org/0000-0002-6937-1411)
- Alberto de Oliveira
- Carlos Henrique Gomes Martins (ORCID: https://orcid.org/0000-0001-8634-6878)
- F. Aquino (ORCID: https://orcid.org/0000-0003-3739-6603)
- Mário Machado Martins (ORCID: https://orcid.org/0000-0001-7381-2788)
- Sérgio A.L. Morais (ORCID: https://orcid.org/0000-0002-1870-612X)
- Rodrigo Rodrigues Franco (ORCID: https://orcid.org/0000-0002-9138-311X)
- Mariana B. Santiago (ORCID: https://orcid.org/0000-0002-6060-379X)
- Julia Silveira Queiroz (ORCID: https://orcid.org/0000-0003-3018-5280)
- Heitor Cappato Guerra Silva (ORCID: https://orcid.org/0000-0001-7000-4451)
- Luís Carlos Scalon Cunha (ORCID: https://orcid.org/0000-0002-4796-2480)
- Joed Pires de Lima Júnior (ORCID: https://orcid.org/0000-0001-6886-281X)
- ALESSANDRA DA FONSECA CEREJA FERREIRA (ORCID: https://orcid.org/0000-0003-0299-7054)
Institutions
- Instituto Federal de Educação, Ciência e Tecnologia do Triângulo Mineiro (BR)
- Universidade Federal de Uberlândia (BR)
Publication Details
- Journal
- Anais da Academia Brasileira de Ciências
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1590/0001-3765202520241067
- Citations
- 1
- Primary Topic
- Natural Antidiabetic Agents Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.29