Total Synthesis and Determination of the Absolute Configuration of Shodoamide C: An Amphotericin B Potentiator against <i>Candida albicans</i>

The total synthesis and structural determination of shodoamide C (<b>1</b>), a compound that enhances the activity of amphotericin B against <i>Candida albicans</i>, have been achieved. A synthetic strategy for compound <b>1</b> facilitated the efficient synthesis of all 16 stereoisomers, allowing for the identification of the four previously unknown stereocenters of <b>1</b> through the chiral recycle HPLC analyses. All stereoisomers of <b>1</b> showed similar activity, indicating that their stereochemistries minimally influenced it.