Identification of a novel biomarker of antibody-mediated rejection in heart transplantation: synergistic effect of anti-nuclear antibodies and de novo donor-specific IgG HLA antibodies
This study establishes circulating IgG dnDSA as an independent biomarker for ABMR diagnosis in heart transplantation and confirms the previously known correlation of IgG dnDSA with ABMR. Subsequently, our data revealed that circulating IgG dnDSA and non-HLA antinuclear antibodies have synergistic effects that cause antibody-mediated rejection in heart transplantation.
Authors
- Gene Kim (ORCID: https://orcid.org/0000-0001-6461-1992)
- Maneesh Kumar Misra (ORCID: https://orcid.org/0000-0002-3757-3326)
- Phillip McMullen (ORCID: https://orcid.org/0000-0001-9984-135X)
- Susana R. Marino (ORCID: https://orcid.org/0000-0003-4369-018X)
Institutions
- University of Chicago (US)
- Stanford University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1550779
- Citations
- 2
- Primary Topic
- Transplantation: Methods and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 4.01