Association of Hypoxia-Inducible Factor-1A Gene Polymorphisms and Infertility: A Case-Control Study from Northwest India

Objectives Infertility is a worldwide health problem, with one in six couples suffering from it and posing a major economic burden on the global healthcare industry. Oxidative stress is a condition depicted as an increased rate of cellular damage persuaded by oxygen-derived oxidants, mainly known as reactive oxygen species. It plays an important role in the pathophysiology of male and female infertility. Reactive oxygen species instigate a significant role in the hypoxia pathway by activating hypoxia-inducible factor-1a. In the present study, the three polymorphisms of HIF1A c.1744C>T, c.1762G>A, and c.83C>A were evaluated to find their interrelation with infertility in patients from northwest India. Material and Methods A total of 400 participants, including 200 infertile individuals (100 couples) as cases and 200 healthy fertile controls, were enrolled for this study. The polymerase chain reaction-restriction fragment length polymorphism method was used to assess the genotypes. Results For the c.1744C>T polymorphism, the frequency of CC, CT, and TT genotypes among cases and controls was found to be slightly different, but all the cases and controls had the wild-type CC genotype of c.83C>A and the GG genotype of the c.1762G>A polymorphism of HIF1A. Conclusion The three HIF1A polymorphisms (c.1744C>T, c.1762G>A, c.83C>A) showed no association with infertility risk in northwest Indian patients.