Attenuation of cisplatin-induced acute kidney injury by sanguinarine: modulation of oxidative stress, inflammation, and cellular damage
In conclusion, SANG mitigated CP-induced AKI by reducing inflammation, oxidative stress, DNA damage, apoptosis, and autophagy. Pending more comprehensive pharmacological and toxicological assessments, SANG may be regarded as a potential therapeutic agent for mitigating CP-induced AKI.
Authors
- Ozaz Elzaki (ORCID: https://orcid.org/0009-0004-2594-7409)
- Abderrahim Nemmar (ORCID: https://orcid.org/0000-0002-0699-1015)
- Nur Elena Zaaba
- Suhail Al‐Salam (ORCID: https://orcid.org/0000-0003-0109-5964)
- Badreldin H. Ali (ORCID: https://orcid.org/0000-0001-6491-6278)
- Sumaya Beegam
- Fatima Aldhaheri
Institutions
- Gulf Medical University (AE)
- United Arab Emirates University (AE)
- Sultan Qaboos University Hospital (OM)
- Sultan Qaboos University (OM)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-02
- DOI
- https://doi.org/10.3389/fphar.2025.1567888
- Citations
- 4
- Primary Topic
- Chemotherapy-induced organ toxicity mitigation
- Type
- article
- Field-Weighted Citation Impact
- 5.89