First‐time cefuroxime target tissue concentrations in long‐lasting spine surgery: Continuous evaluation after repeated weight‐dosed administrations
Repeated weight-dosed intravenous cefuroxime administrations (20 mg/kg) provided homogenous and sufficient intraoperative target tissue exposure of cefuroxime (100% fT>MIC4) in long-lasting spine surgery with hypotensive anaesthesia and postoperative exposure (>4 μg/mL) for 5.5-7.5 h.
Authors
- Mats Bue (ORCID: https://orcid.org/0000-0001-7215-8323)
- Sara Kousgaard Tøstesen (ORCID: https://orcid.org/0000-0002-2960-2342)
- Pelle Hanberg (ORCID: https://orcid.org/0000-0002-6845-1874)
- Magnus A. Hvistendahl (ORCID: https://orcid.org/0000-0002-4086-0238)
- Kristian Høy (ORCID: https://orcid.org/0000-0002-2551-5778)
- Maiken Stilling (ORCID: https://orcid.org/0000-0002-4530-2075)
- Sofus Vittrup (ORCID: https://orcid.org/0000-0001-7109-0726)
Institutions
- Aarhus University (DK)
- Aarhus University Hospital (DK)
Publication Details
- Journal
- British Journal of Clinical Pharmacology
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/bcp.70052
- Primary Topic
- Surgical site infection prevention
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Gigtforeningen
- Helga og Peter Kornings Fond
- Riisfort Fonden