Therapeutic potential and mechanistic insights of silibinin targeting cancer-associated fibroblasts in colorectal cancer
These results demonstrated that SB holds promise as a therapeutic agent for targeting CAFs in CRC. This study advances our understanding of SB's mechanisms, particularly its inhibitory effects on CAFs proliferation, colony formation, and migration.
Authors
- K.X. Zhu
- Youlan Chen (ORCID: https://orcid.org/0000-0002-4304-5693)
- Xiaowen Xu (ORCID: https://orcid.org/0000-0001-7414-0354)
- Jianmei Ji
- Shenglan He
Institutions
- Second Military Medical University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Changhai Hospital (CN)
- Shuguang Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-02
- DOI
- https://doi.org/10.3389/fphar.2025.1527871
- Citations
- 3
- Primary Topic
- Silymarin and Mushroom Poisoning
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- Shanghai Science and Technology Development Foundation
- National Natural Science Foundation of China