Irisin protects against cerebral ischemia reperfusion injury in a SIRT3-dependent manner
Our data shown that irisin exerted a protective role in CIR injury, at least in part, through SIRT3 activation. This study establishes the irisin/SIRT3 as a novel therapeutic target for ischemic stroke, providing mechanistic insights for future interventions.
Authors
- Sihua Qi (ORCID: https://orcid.org/0000-0002-1481-7498)
- Rui Guo (ORCID: https://orcid.org/0000-0001-8147-2736)
- Chenglong Li (ORCID: https://orcid.org/0000-0003-0348-7259)
- Yushuang Cong
- Qi Li (ORCID: https://orcid.org/0000-0003-3925-4107)
Institutions
- Harbin Medical University (CN)
- Peking University (CN)
- Fourth Affiliated Hospital of Harbin Medical University (CN)
- Peking University People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-01
- DOI
- https://doi.org/10.3389/fphar.2025.1558457
- Citations
- 6
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 6.99