Unveiling purine metabolism dysregulation orchestrated immunosuppression in advanced pancreatic cancer and concentrating on the central role of NT5E
This study demonstrates that PM metabolic disorders could impinge upon tumor immunotherapy and exacerbate the immunosuppression engendered by the progression of PC fibrosis. Therapeutic strategies targeting PM or NT5E may offer a ray of hope for patients with advanced PDAC.
Authors
- Junqian Zhang (ORCID: https://orcid.org/0000-0003-2799-9347)
- Ruixin Wu (ORCID: https://orcid.org/0009-0008-8222-3721)
- Changsheng Dong
- Xiaobo Zhang (ORCID: https://orcid.org/0009-0005-0532-6100)
Institutions
- Henan University of Science and Technology (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Longhua Hospital Shanghai University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Henan University of Science and Technology (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-01
- DOI
- https://doi.org/10.3389/fimmu.2025.1569088
- Citations
- 5
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 5.23