Pharmacokinetic boosting of olaparib: Study protocol of a multicentre, open-label, randomised, non-inferiority trial (PROACTIVE-B)
The PROACTIVE study has been published at ClinicalTrials.gov under NCT05078671 on October 14, 2021 and at EudraCT under 2021-004032-28 on August 24, 2021.
Authors
- Alwin D. R. Huitema (ORCID: https://orcid.org/0000-0003-1939-4639)
- Frans L. Opdam (ORCID: https://orcid.org/0000-0002-9489-6535)
- Rob ter Heine (ORCID: https://orcid.org/0000-0003-2185-8201)
- Ingrid A Boere (ORCID: https://orcid.org/0000-0002-4857-6346)
- Marjolijn J. L. Ligtenberg (ORCID: https://orcid.org/0000-0003-1290-1474)
- Nielka P. van Erp (ORCID: https://orcid.org/0000-0003-1553-178X)
- Wietske Kievit (ORCID: https://orcid.org/0000-0002-3984-1769)
- Gabe S. Sonke (ORCID: https://orcid.org/0000-0001-8088-9628)
- Niels A.D. Guchelaar (ORCID: https://orcid.org/0000-0001-8080-9093)
- Joanneke K. Overbeek (ORCID: https://orcid.org/0000-0002-8802-4124)
- Petronella B. Ottevanger (ORCID: https://orcid.org/0000-0001-8209-487X)
- Haiko J. Bloemendal (ORCID: https://orcid.org/0000-0002-8902-4337)
- Stijn L.W. Koolen (ORCID: https://orcid.org/0000-0002-0973-7530)
- Ron H.J. Mathijssen (ORCID: https://orcid.org/0000-0001-5667-5697)
- Ma Ida Mohmaed Ali (ORCID: https://orcid.org/0000-0002-6853-6763)
- Muriëlle Sark
- Carolien Hovenier (ORCID: https://orcid.org/0009-0005-3473-5421)
Institutions
- Radboud University Nijmegen (NL)
- Utrecht University (NL)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- The Netherlands Cancer Institute (NL)
- University Medical Center Utrecht (NL)
- Borstkankervereniging Nederland (NL)
- Oncode Institute (NL)
- Florence (Netherlands) (NL)
- Princess Máxima Center (NL)
- Erasmus MC Cancer Institute (NL)
Publication Details
- Journal
- Contemporary Clinical Trials Communications
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1016/j.conctc.2025.101477
- Citations
- 2
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Amgen
- ZonMw
- Nederlandse Federatie van Universitair Medische Centra