A Direct Comparative Analysis of HPV DNA with Single-Molecule RNA and p16INK4a Protein Expression in Lichen Sclerosus: Implications for Diagnostics and Pathogenesis
HPV DNA was detected in a mosaic pattern across the prepuce, with no significant differences between MGLSc and non-MGLSc skin. The absence of transcriptional activity suggests that HPV in MGLSc is incidental and may not contribute toward pathogenesis.
Authors
- Georgios Kravvas (ORCID: https://orcid.org/0000-0002-1924-0149)
- Clareann H. Bunker (ORCID: https://orcid.org/0000-0002-6693-7483)
- Magnus Lynch
- Henk van den Munckhof
- Maurits de Koning
- Sandra Jerković Gulin (ORCID: https://orcid.org/0000-0002-1051-043X)
- Ellen H. A. van den Munckhof (ORCID: https://orcid.org/0000-0003-4100-4529)
- Michael Millar (ORCID: https://orcid.org/0000-0002-5675-9679)
- Alex Freeman (ORCID: https://orcid.org/0000-0001-5031-3791)
- Aamir Ahmed (ORCID: https://orcid.org/0000-0001-7405-5336)
- Aiman Haider (ORCID: https://orcid.org/0000-0002-7005-4245)
- Boyu Xie (ORCID: https://orcid.org/0000-0002-3966-3261)
- Hussain M. Alnajjar (ORCID: https://orcid.org/0000-0001-6364-0310)
- Asıf Muneer (ORCID: https://orcid.org/0000-0003-2958-1614)
- Clarisse Gânier
Institutions
- Linköping University (SE)
- University College London Hospitals NHS Foundation Trust (GB)
- King's College London (GB)
- Biomedical Primate Research Centre (NL)
- European Patent Organisation (NL)
- Ryhov Hospital Jönköping (SE)
- The Queen's Medical Research Institute (GB)
- University College London (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- JID Innovations
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1016/j.xjidi.2025.100367
- Citations
- 4
- Primary Topic
- Genital Health and Disease
- Type
- article
- Field-Weighted Citation Impact
- 8.03
Funders
- British Skin Foundation