Development of solid drug nanoparticle dispersions for pulmonary delivery of niclosamide and nitazoxanide <i>via</i> vibrating mesh nebulisation
Repurposing very poorly soluble drug compounds for new administration routes is highly challenging; however, we present nebulisable aqueous drug particle dispersions of two agents with appreciable anti SARS-CoV-2 activity for pulmonary delivery.
Authors
- Andrew O’Sullivan (ORCID: https://orcid.org/0000-0002-5434-1260)
- Steve P. Rannard (ORCID: https://orcid.org/0000-0002-6946-1097)
- Andrew A. Dwyer (ORCID: https://orcid.org/0000-0002-7023-6794)
- Catherine Unsworth (ORCID: https://orcid.org/0000-0002-2748-8283)
- Tom O. McDonald (ORCID: https://orcid.org/0000-0002-9273-9173)
- Jonathan Massam
- J. Hobson (ORCID: https://orcid.org/0000-0003-2551-1774)
- Ronan MacLoughlin (ORCID: https://orcid.org/0000-0002-3164-1607)
- Alison C. Savage (ORCID: https://orcid.org/0000-0002-5312-9946)
- Andrew Owen (ORCID: https://orcid.org/0000-0002-9819-7651)
- Paul Curley (ORCID: https://orcid.org/0000-0003-4596-2708)
Institutions
- University of Liverpool (GB)
- Aerogen (Ireland) (IE)
Publication Details
- Journal
- RSC Pharmaceutics
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5pm00006h
- Citations
- 1
- Primary Topic
- Inhalation and Respiratory Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- UK Research and Innovation
- Engineering and Physical Sciences Research Council