PHYSICOCHEMICAL CHARACTERISTICS, ANTIOXIDANTPROPERTIES AND THE EFFECT OF THE NEWLY SYNTHESIZEDPEPTIDE ON LIPID DEPOSITION IN CELLS

A novel peptide, CG-16, with the sequence CHAECGAACKEFCLEG, was designed and synthesized. Studies were conducted to assess its physicochemical properties, antioxidant activity, and effects on lipid deposition in cells in an in vitro experiment. It was established that the CG-16 peptide does not contain antigenic determinants. A search across the PeptideAtlas, UniProt, and the National Center for Biotechnology Information (NCBI) databases confirmed the uniqueness of the synthesized peptide. The prediction of key physicochemical properties of CG-16, including molecular weight, the number of hydrogen bond acceptors and donors, the number of rings, the number of atoms in the largest ring, overall charge, rigidity, flexibility, topological polar surface area, predicted solubility, and the number of acidic sites, suggests that this peptide could be effectively used as a biologically active compound. Furthermore, CG-16 demonstrated antioxidant activity and the ability to reduce lipid accumulation in cells.