Antibacterial Properties of Polymeric Membranes Containing Doxycycline for Potential Applications in Foot Ulcer Treatment
Membranes made from biopolymers and loaded with doxycycline were investigated for potential use in the treatment of foot ulcers in diabetic patients. Carboxymethylcellulose (CMC) and chitosan (CHS) membranes were fabricated with 7% glycerol and 1% doxycycline (DOX). Their mechanical and physical properties, biocompatibility, and antimicrobial effects were thoroughly evaluated. The results demonstrated effective antibacterial activity against <i>S. aureus</i> and <i>S. mutans</i>. Based on the mechanical, physical, and hemolytic data, DOX-loaded CMC/CHS/G membranes show promise as a topical wound delivery system.
Authors
- Alberto V. Jerezano (ORCID: https://orcid.org/0000-0003-2970-6499)
- Paola G. Gordillo (ORCID: https://orcid.org/0000-0002-4600-5574)
- Abigailt Flores‐Ledesma (ORCID: https://orcid.org/0000-0002-8136-4820)
- B.I. Cerda-Cristerna (ORCID: https://orcid.org/0000-0003-1022-1387)
- Eric Reyes‐Cervantes (ORCID: https://orcid.org/0000-0001-6436-0900)
- J.L. Suárez-Franco (ORCID: https://orcid.org/0000-0003-0234-0570)
- Brenda Castillo (ORCID: https://orcid.org/0000-0003-0142-895X)
- Laura Abisaí Pazos-Rojas (ORCID: https://orcid.org/0000-0002-0945-4012)
- Diana del C. Pazos-Guarneros
- Ismael Juárez-Díaz
- Carolina Sámano-Valencia (ORCID: https://orcid.org/0000-0002-3357-4372)
- Stevaly Pérez-Gutiérrez
- Alejandro G. Martínez-Guerrero
- Gisela N. Rubin de Celis-Quintana
- Jesús Ángel Ramírez-Enciso
Institutions
- Universidad Veracruzana (MX)
- Universidad Autónoma Metropolitana (MX)
- Benemérita Universidad Autónoma de Puebla (MX)
- Tecnológico de Monterrey (MX)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2025-04-01
- DOI
- https://doi.org/10.3390/ijms26073274
- Citations
- 1
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.03
Funders
- Instituto Tecnológico y de Estudios Superiores de Monterrey
- Benemérita Universidad Autónoma de Puebla