Differential immunoregulation by human surfactant protein A variants determines severity of SARS-CoV-2-induced lung disease
These findings demonstrate that human SP-A variants differentially modulate SARS-CoV-2-induced lung injury and disease severity by differentially inhibiting viral infectivity and regulating immune-related gene expressions.
Authors
- Ikechukwu B. Jacob
- Hongkuan Fan (ORCID: https://orcid.org/0000-0002-9441-9405)
- Erin S. Reynolds (ORCID: https://orcid.org/0000-0002-2847-0982)
- Qinghe Meng
- Hongpeng Jia (ORCID: https://orcid.org/0000-0001-6783-7532)
- Salma S. Mahmoud
- Guirong Wang (ORCID: https://orcid.org/0000-0002-3794-0106)
- Saravanan Thangamani (ORCID: https://orcid.org/0000-0002-4269-5993)
- Paul T. Massa (ORCID: https://orcid.org/0000-0001-9584-8212)
- Emerson M. Kopsack
- Akinkunmi O. Lawal
Institutions
- Johns Hopkins University (US)
- Medical University of South Carolina (US)
- SUNY Upstate Medical University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1462278
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00