Outcomes following isolated right ventricular assist device as durable support for primary right heart failure: An INTERMACS analysis
Outcomes with isolated right ventricular assist devices (iRVAD) using pumps designed for the left ventricle are not well described. This study compares the clinical characteristics and outcomes of iRVAD patients to those patients treated with left ventricular assist device (LVAD) and biventricular assist devices (BiVAD). This study consisted of patients who received iRVAD from the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) registry (2006-2017). The primary outcome was 2-year survival. Of 20,789 patients, 26 (0.13%) received iRVAD, 17 with pulsatile flow and 9 with continuous-flow devices. Device strategy was bridge to recovery/rescue therapy in 9 (35%), bridge to transplant/decision in 14 (52%), and destination therapy in 3 (12%). Twelve (46%) patients were INTERMACS profile 1, 5 patients (19%) required extracorporeal membrane oxygenation, and 13 (50%) needed mechanical ventilation. Two-year survival for patients with iRVAD (41.3%) was similar to BiVAD (45.2%) and significantly lower than LVAD (69.0%). In patients with isolated right-sided failure, long-term iRVAD support is feasible.
Authors
- Navin Kumar Kapur (ORCID: https://orcid.org/0000-0002-8302-6796)
- Pavan Atluri (ORCID: https://orcid.org/0000-0003-0229-085X)
- Allison Padegimas
- Matthew Seigerman (ORCID: https://orcid.org/0000-0001-6188-5760)
- Edo Y. Birati (ORCID: https://orcid.org/0000-0002-7933-7794)
- Fausto Cabezas
- J. Eduardo Rame (ORCID: https://orcid.org/0000-0002-2936-1702)
- Francis D. Pagani (ORCID: https://orcid.org/0000-0003-4430-9969)
- Matthew C. Kiernan (ORCID: https://orcid.org/0000-0001-9054-026X)
- Robert Zhang (ORCID: https://orcid.org/0000-0002-7946-6094)
- Jeremy A. Mazurek (ORCID: https://orcid.org/0000-0002-3332-0102)
- Jeffrey J. Teuteberg (ORCID: https://orcid.org/0000-0002-8342-3222)
- Edward Wilson Grandin (ORCID: https://orcid.org/0000-0002-4287-334X)
- Keshava Rajagopal (ORCID: https://orcid.org/0000-0001-9352-1259)
- S.L. Myers
- Michael A. Acker
- Guilherme H. Oliveira
- James K Kirklin
- Robert L. Kormos
Institutions
- Tufts Medical Center (US)
- Beth Israel Deaconess Medical Center (US)
- Bar-Ilan University (IL)
- Thomas Jefferson University (US)
- University of Pittsburgh (US)
- Palo Alto University (US)
- Cornell University (US)
- University of Michigan (US)
- Thomas Jefferson University Hospital (US)
- Tampa General Hospital (US)
- University of Alabama at Birmingham (US)
- Michigan Medicine (US)
- Stanford Medicine (US)
- Jefferson Hospital (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- JHLT Open
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1016/j.jhlto.2025.100258
- Primary Topic
- Mechanical Circulatory Support Devices
- Type
- article
- Field-Weighted Citation Impact
- 0.00