Therapeutic efficacy of artemether–lumefantrine in North-Eastern states of India and prevalence of drug resistance-associated molecular markers
This study reports that AL is efficacious against uncomplicated P. falciparum cases in NE states of India. However, prevalence of mutations in molecular marker associated with anti-malarial resistance (pfmdr1, pfdhfr, pfdhps and pfk13) gene indicate possible emergence of drug resistance. This is to underline the fact that the drug is efficacious for now, but rising mutations indicate that continuous monitoring is essential for effective treatment regime.
Authors
- Soni Kumari
- Sushrikanta Khandai
- Sweta Mishra
- Anil Verma (ORCID: https://orcid.org/0000-0002-3105-4138)
- Praveen Kumar Bharti (ORCID: https://orcid.org/0000-0003-2548-4884)
- Anup Anvikar (ORCID: https://orcid.org/0000-0001-8455-6054)
- Shreelekha Dutta (ORCID: https://orcid.org/0000-0001-8091-2875)
- Anup K. Vishwakarma
- Disphikha Goswami
- Sri Krishna (ORCID: https://orcid.org/0000-0003-4994-3758)
- Aparup Das (ORCID: https://orcid.org/0000-0002-4081-5816)
- Kuldeep Singh (ORCID: https://orcid.org/0009-0002-8183-2628)
- Nazia Ali (ORCID: https://orcid.org/0000-0001-6638-0649)
Institutions
- National Institute for Research in Tribal Health (IN)
- National Institute of Malaria Research (IN)
Publication Details
- Journal
- Malaria Journal
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1186/s12936-025-05338-1
- Citations
- 1
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- World Health Organization