Genomic insights into monensin resistance development in Eimeria tenella
The genetic diversity of MR parasites remained stable across generations, despite varying drug concentrations. Seven candidate genes with 11 missense mutations were identified in MR strains. Key genes include ETH2_0729200 (dynein motor protein), ETH2_0729400 (esterase/lipase), and ETH2_0730000 (pyridine nucleotide-disulfide oxidoreductase) annotated in both the selective sweeps by using ΔSNP-index and F<sub>ST</sub> methods. Further experimental validation of these candidate genes is essential to elucidate their roles in monensin resistance. This research contributes valuable insights into the molecular basis of resistance pressure in <i>Eimeria</i> parasites, potentially informing future strategies for the control of coccidiosis.
Authors
- Yubo Shi (ORCID: https://orcid.org/0000-0002-5664-7511)
- Ping Cui (ORCID: https://orcid.org/0000-0002-6918-3103)
- Hongbin Liu (ORCID: https://orcid.org/0000-0002-7139-9851)
- Sufang Fang
- Xinming Tang (ORCID: https://orcid.org/0000-0003-0127-1235)
- Yuanyuan Zhang (ORCID: https://orcid.org/0009-0005-6934-8245)
- Peng Wang (ORCID: https://orcid.org/0000-0001-8350-691X)
- Gu Xiaolong
Institutions
- Hebei North University (CN)
- Institute of Animal Sciences (CN)
- China Agricultural University (CN)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2025-04-01
- DOI
- https://doi.org/10.3389/fvets.2025.1459791
- Citations
- 1
- Primary Topic
- Coccidia and coccidiosis research
- Type
- article
- Field-Weighted Citation Impact
- 1.19
Funders
- Hebei North University
- Natural Science Foundation of Hebei Province