Higher levels of VEGF-A and TNFα in patients with immune checkpoint inhibitor-induced inflammatory arthritis
Elevated levels of VEGF-A and TNFα are associated with ICI-IA. There was also higher IL-6 and VEGF-A among those with higher disease activity when controlling for confounding. These cytokines could be used as biomarkers of ICI-IA severity and present therapeutic targets.
Authors
- Ami A. Shah (ORCID: https://orcid.org/0000-0002-1139-2009)
- Jennifer H. Elisseeff (ORCID: https://orcid.org/0000-0002-5066-1996)
- Julie R. Brahmer (ORCID: https://orcid.org/0000-0002-2443-8395)
- Laura C. Cappelli (ORCID: https://orcid.org/0000-0003-2795-7059)
- Jennifer S. Mammen (ORCID: https://orcid.org/0000-0001-9929-590X)
- Valsamo Anagnostou (ORCID: https://orcid.org/0000-0001-9480-3047)
- Patrick M. Forde (ORCID: https://orcid.org/0000-0001-6925-6344)
- Joseph C. Murray (ORCID: https://orcid.org/0000-0001-6159-7814)
- Elise Gray-Gaillard (ORCID: https://orcid.org/0000-0002-9832-6556)
- Clifton O. Bingham (ORCID: https://orcid.org/0000-0002-4752-5029)
Institutions
- Bloomberg (United States) (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Johns Hopkins Bayview Medical Center (US)
- Sidney Kimmel Cancer Center (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1186/s13075-025-03546-3
- Citations
- 4
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- National Institutes of Health
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University