Gusongan capsule enhances osteogenic differentiation to mitigate bone loss in ovariectomized rats via the TLR2/NF-κB pathway
This study highlighted that GSA capsule attenuated inflammation and augmented osteogenic differentiation of BMSCs by targeting the TLR2/NF-κB pathway. These molecular mechanisms contributed to enhanced BMD and bone microarchitecture in OVX rats, suggesting the therapeutic potential of GSA capsule in OP management.
Authors
- Guihong Liang (ORCID: https://orcid.org/0000-0002-7599-2628)
- Di Zhao (ORCID: https://orcid.org/0000-0001-6253-7127)
- Jianke Pan (ORCID: https://orcid.org/0000-0002-4596-6111)
- Lingfeng Zeng
- Jinlong Zhao (ORCID: https://orcid.org/0000-0001-7079-1336)
- Guanghui Zhou
- Jun Liu (ORCID: https://orcid.org/0000-0002-1943-3880)
- Junzheng Yang
- Zhuoxu Gu
- Weiyi Yang (ORCID: https://orcid.org/0000-0001-8657-2269)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1016/j.phymed.2025.156705
- Citations
- 1
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.81