BNIP3-mediated mitophagy aggravates placental injury in preeclampsia via NLRP1 inflammasome
These findings reveal a novel mechanism through which BNIP3-mediated mitophagy exacerbates H/R-induced placental injury by inducing mtROS production and activating the NLRP1 inflammasome in PE.
Authors
- Man Zhao (ORCID: https://orcid.org/0000-0003-2631-1977)
- Changqing Zhang (ORCID: https://orcid.org/0000-0002-8311-8607)
- Junjun Guo (ORCID: https://orcid.org/0009-0005-6913-9996)
- Meihua Zhang (ORCID: https://orcid.org/0000-0002-6821-1168)
- Anna Li (ORCID: https://orcid.org/0000-0002-4180-6153)
- Yan Kang (ORCID: https://orcid.org/0000-0002-0967-7849)
- Meijuan Zhou (ORCID: https://orcid.org/0000-0003-3498-2690)
- Zhenya Fang
- Zexin Yang
- Chunying Wang (ORCID: https://orcid.org/0000-0003-4767-4523)
Institutions
- Qingdao University (CN)
- National Health and Family Planning Commission (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1530015
- Citations
- 1
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 2.06