IL-12-producing cytokine factories induce precursor exhausted T cells and elimination of primary and metastatic tumors
Our new immunotherapy approach provides a robust strategy for inducing Tpex recruitment and systemic immunity against a range of solid peritoneal malignancies, many incurable with current immunotherapy strategies. Notably, these features were achieved using IL-12, and by leveraging our technology, we avoided the toxicities that have prevented the translation of IL-12 to the clinic. Our findings provide a strong rationale for the clinical development of IL-12 cytokine factories.
Authors
- Bertha Castillo
- Amanda Nash (ORCID: https://orcid.org/0000-0002-7704-4912)
- Oleg A. Igoshin (ORCID: https://orcid.org/0000-0002-1449-4772)
- Danna Murungi
- H. Courtney Hodges (ORCID: https://orcid.org/0000-0003-4441-497X)
- Omid Veiseh (ORCID: https://orcid.org/0000-0003-1153-8079)
- José Oberholzer (ORCID: https://orcid.org/0000-0002-1069-2501)
- Ningbo Zheng (ORCID: https://orcid.org/0000-0002-3684-5596)
- Jonathon DeBonis (ORCID: https://orcid.org/0009-0004-8965-383X)
- Andrea Hernández
- Sofia Ghani
- Ira Joshi (ORCID: https://orcid.org/0009-0001-6313-567X)
- Annie L. Nguyen (ORCID: https://orcid.org/0009-0004-4951-3808)
- Peter Rios (ORCID: https://orcid.org/0000-0003-0472-4746)
- Weiyi Peng (ORCID: https://orcid.org/0000-0002-7785-6240)
- Fangheng Hu
- Zeshi Wang (ORCID: https://orcid.org/0009-0006-0763-3259)
- Boram Kim (ORCID: https://orcid.org/0000-0002-4758-4547)
- Nathan E. Reticker-Flynn (ORCID: https://orcid.org/0000-0002-9963-039X)
- Courtney Chambers (ORCID: https://orcid.org/0000-0002-2754-8282)
- Douglas Isa
Institutions
- Baylor College of Medicine (US)
- University Hospital of Zurich (CH)
- TransUnion (United States) (US)
- Center for Theoretical Biological Physics (US)
- Cell Medica (Switzerland) (CH)
- University of Houston (US)
- Rice University (US)
- Stanford University (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1136/jitc-2024-010685
- Citations
- 7
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 7.32
Funders
- Cancer Prevention and Research Institute of Texas
- Rice University
- Advanced Research Projects Agency
- Common Fund