Targeting PD-1 and CD85j can restore intratumoral CD4<sup>+</sup> GzmB<sup>+</sup> T-cell functions to combat MHC-II-expressing tumors
Our study demonstrated that tumor-infiltrating CD4<sup>+</sup>GzmB<sup>+</sup> T cells fail to eliminate tumors. Dual blockade of PD-1 and CD85j alongside IL-15 restores the effector function of CD4<sup>+</sup>GzmB<sup>+</sup> T cells and drives CD4<sup>+</sup>GzmB<sup>+</sup> T-cell transformation in the tumor microenvironment to combat MHC-II-expressing tumors.
Authors
- Chenxi Zeng (ORCID: https://orcid.org/0000-0001-7189-8637)
- Xu Wang (ORCID: https://orcid.org/0000-0002-3768-777X)
- Yitao Tian (ORCID: https://orcid.org/0009-0007-7727-8130)
- Rirong Qu (ORCID: https://orcid.org/0000-0002-3334-3304)
- Shengling Fu
- Shaojie Hu (ORCID: https://orcid.org/0000-0002-1561-422X)
- Tianlai Wang (ORCID: https://orcid.org/0009-0004-5836-7750)
- Zhiwei Yuan
- Weidong Zou (ORCID: https://orcid.org/0000-0002-1332-4878)
- Xiangning Fu (ORCID: https://orcid.org/0000-0003-4670-1438)
- B. Wang (ORCID: https://orcid.org/0009-0003-9284-9852)
- Yu Xi (ORCID: https://orcid.org/0000-0001-6385-8862)
- Xue Wang (ORCID: https://orcid.org/0000-0003-3603-6104)
- Lequn Li (ORCID: https://orcid.org/0000-0002-6582-142X)
- Yixin Cai
- Kelin Meng
- Taiyan Yu
- Hui Xiong (ORCID: https://orcid.org/0000-0002-4564-7794)
Institutions
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1136/jitc-2024-010890
- Citations
- 5
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 3.99
Funders
- National Natural Science Foundation of China
- Huazhong University of Science and Technology
- Tongji University
- Tongji Medical College, Huazhong University of Science and Technology